A grey smoothing model for predicting mine gas emission was presented by combining the grey system theory with the smoothing prediction technique. First of all, according to the variable sequence, GM(1,1) model was set up to predict the general development trend of variable as first fitted values, then the smoothing prediction technique was used to revise the fitted values so as to improve the accuracy of prediction. The results of application in the No.6 Coal Mine in Pingdingshan mining area show that the grey smoothing model has higher accuracy than that of GM(1,1) in predicting the variable sequence with strong fluctuation. The research provides a new scientific method for predicting mine gas emission.